herg k — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1278	Astemizole	Laridal,Histaminos,Paralergin	Potassium Channel , Histamine Receptor
	Astemizole (Laridal) is a synthetic piperidinyl-benzimidazol derivative with antiallergic properties, acts as a reversible competitive inhibitor of histamine H1 receptors, with less anticholinergic effects compared to re...		Potassium Channel , Histamine Receptor
T13619	Cloperastine fendizoate	Hustazol	EGFR
	Cloperastine fendizoate (Hustazol) inhibits the hERG K+ currents in a concentration-dependent manner (IC50: 27 nM).		EGFR
TQ0139	VU 0240551	N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide,VU0240551-2-D4	Potassium Channel , Calcium Channel , HER
	VU 0240551 is a selective antagonist of neuronal K-Cl cotransporter KCC2 inhibitor with an IC50 of 560 nM. VU 0240551 inhibits L-type calcium channels and hERG.		Potassium Channel , Calcium Channel , HER
T16265	Naluzotan	PRX 00023	EGFR , 5-HT Receptor
	Naluzotan（PRX 00023） is a novel and potent 5-HT1A agonist with IC50 and Ki values of approximately 20 nM and 5.1 nM, respectively.Naluzotan is a potent hERG K+ channel blocker with an IC50 value of 3800 nM.Naluzotan exhi...		EGFR , 5-HT Receptor
T0723	Cloperastine hydrochloride	HT-11 hydrochloride	Potassium Channel , 5-HT Receptor
	Cloperastine hydrochloride (HT-11 hydrochloride) is a type of flavonoid.		Potassium Channel , 5-HT Receptor
T7198	E-4031		EGFR , Potassium Channel
	E-4031 is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM)		EGFR , Potassium Channel
T4341	Betrixaban	PRT054021	Factor Xa
	Betrixaban (PRT054021) is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa [1]. It was selected among all lead compounds due to its low hERG channel ...		Factor Xa
T68113	Naluzotan hydrochloride	PRX 00023 hydrochloride	EGFR , 5-HT Receptor
	Naluzotan hydrochloride (PRX 00023 hydrochloride) is a hERG K+ channel blocker with an IC50 value of 3800 nM and is commonly used in the study of anxiety and depression.Naluzotan hydrochloride is also a novel, potent, an...		EGFR , 5-HT Receptor
T4612	NS309		EGFR , Potassium Channel , HER
	NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels). It can also activat...		EGFR , Potassium Channel , HER
T34616	Seridopidine	ACR-343,ACR 343,ACR343	Dopamine Receptor
	Seridopidine (ACR343) is a modulator of dopaminergic activity that is used as an oral therapy for schizophrenia, Parkinson's disease, and Tourette's syndrome.		Dopamine Receptor
T1066L	Ketanserin tartrate	KJK 945 tartrate,KJK-945 tartrate,KJK945 tartrate	5-HT Receptor , Serotonin Transporter , Adrenergic Receptor
	Ketanserin tartrate (KJK-945 tartrate) is a 5-HT2A receptor and α1-adrenergic receptor antagonist with antihypertensive activity, inhibits serotonin-induced vasoconstriction and platelet activation, and can be used in th...		5-HT Receptor , Serotonin Transporter , Adrenergic Receptor
T4980	Betrixaban maleate		Factor Xa
	Betrixaban maleate is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa.		Factor Xa
TN6051	Songoramine
	Songoramine(10 uM) demonstrates significant hERG K+ channel inhibition.
TN4638	Neolinine		EGFR , Potassium Channel
	Neolinine(at 10uM) shows significant hERG K+ channel inhibition activity.		EGFR , Potassium Channel
T63382	Protease-Activated Receptor-1 antagonist 3
	Protease-Activated Receptor-1 antagonist 3 is a potent antagonist (IC50: 7 nM) of Protease-Activated Receptor 1protease-activated receptor-1. antagonist 3 exhibits binding affinity to hERG K+ channels (IC50: 9 μM).
T15755	Lidoflazine		Calcium Channel
	Lidoflazine is a high-affinity blocker of the HERG K+ channel and is an antianginal calcium channel blocker. It carries an obvious risk of QT interval prolongation and ventricular arrhythmia.		Calcium Channel
T72897	P-CAB agent 2
	P-CAB Agent 2 is a potent, orally active potassium-competitive acid blocker (P-CAB) and gastric acid secretion inhibitor that effectively inhibits H+/K+-ATPase activity, showing an IC50 value of <100 nM. It also demonstr...
T72181	P-CAB agent 2 hydrochloride
	P-CAB agent 2 hydrochloride is a potent, orally active potassium-competitive acid blocker (P-CAB) and gastric acid secretion inhibitor. It effectively inhibits H+/K+-ATPase activity, with an IC50 value of <100 nM, and ta...
T61197	Irdabisant hydrochloride
	Irdabisant hydrochloride (CEP-26401) is a selective, orally active, and blood-brain barrier (BBB) penetrant histamine H3 receptor (H3R) inverse agonist/inverse agonist, demonstrating high affinity with K*i values of 7.2 ...